Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploration of the genetic neuroinflammatory environment in the human midcingulate cortex in Huntington's disease.

Communications medicine·2026

Same author

Insulin Receptor Isoform Pattern in Aged Normal and Alzheimer's Human Cortex.

Journal of neurochemistry·2026

Same author

Development-related gene expression disruption in the human midcingulate cortex in Huntington's disease.

Journal of Huntington's disease·2026

Same author

In Vitro Evaluation of PARP1 Inhibitor Olaparib-Cyanine Dye Conjugate for the Treatment of Glioblastoma.

ChemMedChem·2026

Same author

Clinicopathological features of primary tauopathies: a brain bank series.

Frontiers in neurology·2026

Same author

Central nervous system pericytes express soluble ST2 in inflammation and injury.

Molecular brain·2026

Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 19, 2025

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

Identifying Neural Progenitor Cells in the Adult Human Brain.

Thomas I H Park^1,2, Henry J Waldvogel^2,3, Johanna M Montgomery^2,4

¹Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Methods in Molecular Biology (Clifton, N.J.)

|September 24, 2021

Summary

This summary is machine-generated.

Researchers are developing methods to study human brain progenitor cells for potential cell replacement therapies in neurodegenerative diseases. Understanding these cells is crucial for future treatments.

Keywords:

Brain bank Human brain Neural progenitor cell Neurosphere

More Related Videos

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Published on: September 14, 2015

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Related Experiment Videos

Last Updated: Oct 19, 2025

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics

Published on: September 14, 2015

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Area of Science:

Neuroscience
Stem Cell Biology
Regenerative Medicine

Background:

Adult human brains harbor progenitor cells, with increased expression in degenerative diseases.
These cells offer potential for replacing damaged neurons in neurological conditions.
Significant research is ongoing to understand progenitor cell biology in the human brain.

Purpose of the Study:

To outline methodologies for studying human brain progenitor cells.
To detail techniques for locating, labeling, and isolating these cells.
To describe methods for assessing differentiated progenitor cell electrophysiology.

Main Methods:

Tissue processing and immunohistochemistry.
Autoradiography and progenitor cell culture.
Electrophysiological analysis of differentiated brain cells.

Main Results:

Established unique methods for examining and isolating progenitor cells from surgical and postmortem human brain tissue.
Developed protocols for tissue processing, cell culture, and electrophysiology.
Addressed ethical and technical considerations specific to human brain tissue research.

Conclusions:

The described methods facilitate the study of human brain progenitor cells.
These techniques are essential for advancing cell replacement strategies for neurodegenerative diseases.
Further research into progenitor cell biology is critical for therapeutic applications.