Related Experiment Video
Updated: Oct 19, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
[Retracted] MicroRNA‑22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
Shoulin Zhang1, Dongmei Zhang2, Chunguang Yi3
1Internal Medicine Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China.
Abstract:
Following the publication of this paper, the authors have contacted the Editorial Office to explain that they are unable to reproduce the results of various of their experiments after having repeated some of them, and consequently they wish to retract the paper.owing to a lack of confidence in the presented data. It was also drawn to the attention of the Office that certain of the tumor images shown in Fig. 6A were strikingly similar to data appearing in different form in other articles by different authors. Considering all these points, the Editor of Oncology Reports is in agreement that this paper should be retracted from the Journal. The authors all agree with the decision to retract this paper. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in Oncology Reports 35: 559‑567, 2016; DOI: 10.3892/or.2015.4333].
Related Concept Videos
MicroRNAs
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
Experimental RNAi
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

