Related Experiment Videos
Mark G Rippon1, Alan A Rogers2, Karen Ousey1,3,4
1Huddersfield University, Reino Unido.
Background:
Antimicrobial resistance (AMR) is one of the most serious health threats globally. The development of new antimicrobials is not keeping pace with the evolution of resistant microorganisms, and novel ways of tackling this problem are required. One of such initiatives has been the development of antimicrobial stewardship programmes (AMS). The use of wound dressings that employ a physical sequestration and retention approach to reduce bacterial burden offers a novel approach to support AMS. Bacterial-binding by dressings and their physical removal can minimise their damage and prevent the release of harmful endotoxins.
Objective:
To highlight AMS to promote the correct use of antimicrobials and to investigate how dialkylcarbamyl chloride (DACC)-coated dressings can support AMS.
Method:
MEDLINE, Cochrane Database of Systematic Reviews, and Google Scholar were searched to identify articles relating to AMS, and the use of wound dressings in the prevention and treatment of wound infections. The evidence supporting alternative wound dressings that can reduce bioburden and prevent wound infection in a way that does not kill or damage the microorganisms were reviewed.
Results:
The evidence demonstrated that using bacterial-binding wound dressings that act in a physical manner (eg, DACC-coated dressings) to preventing infection in both acute and hard-to-heal wounds does not exacerbate AMR and supports AMS.
Conclusion:
Some wound dressings work via a mechanism that promotes the binding and physical sequestration and removal of intact microorganisms from the wound bed (eg, a wound dressing that uses DACC technology to prevent/reduce infection). They provide a valuable tool that aligns with the requirements of AMS by effectively reducing wound bioburden without inducing/selecting for resistant bacteria.
Insights
Antimicrobial resistance (AMR) is a global threat. Dialkylcarbamyl chloride (DACC)-coated wound dressings physically remove bacteria, supporting antimicrobial stewardship programmes (AMS) without promoting resistance.
Area of Science:
- Infectious Diseases
- Wound Care
- Microbiology
Background:
- Antimicrobial resistance (AMR) poses a significant global health challenge.
- Novel strategies are needed as antimicrobial development lags behind resistant microorganisms.
- Antimicrobial stewardship programmes (AMS) and innovative wound care are crucial.
Purpose of the Study:
- To emphasize AMS for appropriate antimicrobial use.
- To evaluate dialkylcarbamyl chloride (DACC)-coated dressings as a tool for AMS.
- To explore non-antimicrobial approaches to wound infection management.
Main Methods:
- Literature search of MEDLINE, Cochrane Database of Systematic Reviews, and Google Scholar.
- Review of studies on AMS and wound dressing efficacy.
- Focus on dressings reducing bacterial burden without killing microbes.
Main Results:
- Bacterial-binding wound dressings, such as DACC-coated options, physically reduce bioburden.
- These dressings effectively prevent infection in acute and chronic wounds.
- Evidence shows no exacerbation of AMR, supporting AMS goals.
Conclusions:
- Wound dressings utilizing DACC technology bind and remove intact microorganisms.
- This physical sequestration mechanism reduces wound bioburden effectively.
- These dressings are valuable tools for AMS, mitigating infection without driving resistance.