1,2,3-Triazole hybrids as anticancer agents: A review

Area of Science:

• Medicinal Chemistry
• Drug Discovery
• Oncology

Background:

• Current anticancer agents face challenges including drug resistance and significant side effects.
• There is a critical need for novel, more effective, and safer anticancer therapies.
• 1,2,3-Triazoles are recognized for their significant biological potential in drug development.

Purpose of the Study:

• To provide a comprehensive overview of recent advancements in 1,2,3-triazole hybrids with anticancer properties.
• To analyze the chemical structures, structure-activity relationships (SAR), and mechanisms of action of these novel compounds.
• To include insights from molecular docking studies on these anticancer agents.

Main Methods:

• Literature review focusing on research published within the last two years.
• Analysis of chemical structures and SAR data of 1,2,3-triazole hybrids.
• Examination of reported mechanisms of action and computational docking studies.

Main Results:

• Identification of numerous 1,2,3-triazole hybrids exhibiting promising anticancer activity.
• Correlation between specific structural features and enhanced anticancer efficacy.
• Insights into the molecular interactions and potential targets of these triazole derivatives.

Conclusions:

• 1,2,3-Triazole hybrids represent a promising scaffold for the development of next-generation anticancer drugs.
• Further research into SAR and mechanism of action can optimize drug design for improved safety and efficacy.
• Docking studies provide valuable guidance for the rational design of potent anticancer agents.