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Bifunctional Smart Hydrogel Dressing with Strain Sensitivity and NIR-Responsive Performance.

Fan Hao1, Liangyu Wang1, Binling Chen1

  • 1Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China.

ACS Applied Materials & Interfaces
|September 24, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel smart hydrogel dressing using MXene nanosheets and a temperature-sensitive polymer for real-time health monitoring. The material functions as a strain sensor and a near-infrared light-controlled drug delivery system.

Keywords:
MXeneNIR-responsivehydrogelstrain sensorsurface functionalization

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Smart hydrogels offer potential for real-time human health monitoring due to their responsiveness to various stimuli.
  • Developing advanced hydrogel materials is crucial for improving wearable sensors and targeted drug delivery systems.

Purpose of the Study:

  • To develop a novel smart hydrogel dressing incorporating conductive MXene nanosheets and a temperature-sensitive polymer (PNIPAm).
  • To investigate the hydrogel's properties as a strain-sensitive flexible sensor and a near-infrared (NIR) light-controlled drug release carrier.

Main Methods:

  • Functionalization of MXene nanosheets with γ-methacryloxypropyltrimethoxysilane (KH570) to enhance compatibility with PNIPAm.
  • Fabrication of the K-M/PNIPAm hydrogel composite.
  • Characterization of the hydrogel's strain sensitivity, response to NIR light, and drug release capabilities.

Main Results:

  • The K-M/PNIPAm hydrogel demonstrated significant strain-sensitive properties.
  • As a flexible sensor, it exhibited high strain sensitivity (GF = 4.491), a wide working strain range (≈250%), rapid response time (∼160 ms), and excellent cycle stability.
  • The hydrogel effectively functioned as an NIR light-controlled drug release carrier for on-demand delivery.

Conclusions:

  • The developed K-M/PNIPAm hydrogel shows promise for applications in human health real-time monitoring.
  • Its dual functionality as a strain sensor and a drug delivery system opens new avenues for smart medical devices.