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Updated: Oct 19, 2025
Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Cluster dirhenium(III) cis-dicarboxylates with α-amino acids ligands as mighty selective G4s binders
Nataliia Shtemenko1, Isabel Pont2, Yuliia Husak1
1Department of Inorganic Chemistry, Ukrainian State University of Chemical Technology, 8, Gagarin avenue, Dnipro 49005, Ukraine.
Abstract:
The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G-quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer - melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also strong stabilization activity to HTelo21 quadruplex. At the same time, the compounds do not show any stabilization activity for ds26 DNA, which suggests unique mechanisms of molecular DNA recognition for these complexes.
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