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Updated: Oct 19, 2025
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
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Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions
Xin Wang1,2, Rui Ma3, Xilin Zhang1,2
1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, 1278 Baode Road, Jing'an District, Shanghai, 200443, China.
Molecular Cancer
|September 25, 2021
Summary
N6-methyladenosine (m6A) and circular RNAs (circRNAs) are key regulators in cells. This review explores their interactions, highlighting their roles in biological processes and disease.
Area of Science:
- Molecular Biology
- RNA Biology
- Epigenetics
Background:
- N6-methyladenosine (m6A) is a prevalent RNA modification influencing RNA fate.
- Circular RNAs (circRNAs) are non-coding RNAs involved in various physiological and pathological processes.
- Recent advances highlight the growing interest in the interplay between m6A and circRNAs.
Purpose of the Study:
- To provide a comprehensive overview of m6A modifications and circRNA biology.
- To summarize the current understanding of the crosstalk between m6A and circRNAs.
- To suggest future research directions in this emerging field.
Main Methods:
- Literature review of existing research on m6A and circRNAs.
- Analysis of studies investigating the interaction between m6A and circRNAs.
- Synthesis of current knowledge and identification of research gaps.
Main Results:
- m6A modification affects circRNA biogenesis, stability, and function.
- CircRNAs can influence m6A levels and the activity of m6A-binding proteins.
- The crosstalk between m6A and circRNAs plays significant roles in gene regulation and cellular processes.
Conclusions:
- The interplay between m6A and circRNAs represents a novel layer of gene regulation.
- Understanding this crosstalk is crucial for elucidating complex biological mechanisms and disease pathogenesis.
- Further research is warranted to fully unravel the functional implications and therapeutic potential.
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