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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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Updated: Oct 19, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

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Published on: May 16, 2025

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Age-related differences in acute aortic dissection.

Song Wu1, Chenghao Cao2, Yu Lun1

  • 1Department of Vascular and Thyroid Surgery, The First Hospital, China Medical University, Shenyang, China.

Journal of Vascular Surgery
|September 25, 2021
PubMed
Summary
This summary is machine-generated.

Young patients with acute aortic dissection (AAD) are more likely to be obese and have dissections extending beyond aortic branches. This leads to greater malperfusion risks compared to older patients.

Keywords:
AgeAortic dissectionClinical characteristicsOutcomeTreatments

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Area of Science:

  • Cardiovascular Surgery
  • Vascular Surgery
  • Aortic Diseases

Background:

  • Acute aortic dissection (AAD) is a life-threatening condition with varying clinical presentations across age groups.
  • Understanding age-specific characteristics is crucial for timely diagnosis and management of AAD.

Purpose of the Study:

  • To investigate and compare the clinical characteristics, treatment approaches, and outcomes of patients with acute aortic dissection (AAD) across different age demographics.
  • To identify age-related risk factors and specific features associated with AAD progression.

Main Methods:

  • A retrospective single-center study analyzed 602 patients with AAD from August 2014 to August 2020.
  • Patients were stratified into three groups: <45 years (young), 45-59 years (middle-age), and >59 years (elderly).
  • Type A (TAAD) and Type B (TBAD) aortic dissections were evaluated separately.

Main Results:

  • Younger patients (<45 years) exhibited higher rates of obesity and male sex (86%).
  • Dissections in young patients frequently extended beyond the abdominal aortic branch cluster (AABC) (84% TAAD, 89% TBAD).
  • Intimal flap tear exceeding AABC was significantly associated with younger age (OR, 5.15) and higher D-dimer levels (OR, 1.05), increasing malperfusion risk.

Conclusions:

  • Young AAD patients present with distinct characteristics, including obesity and extensive aortic flap involvement.
  • These factors contribute to a higher incidence of non-true lumen blood supply and increased risks of visceral and lower limb malperfusion.
  • Age <45 years is identified as a significant risk factor for dissections extending beyond aortic branches, necessitating tailored clinical attention.