Related Experiment Video

Updated: Oct 19, 2025

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K

In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis

Jordi Guiu1, Kim B Jensen2

  • 1Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge, L'Hospitalet de Llobregat, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia, L'Hospitalet de Llobregat, Spain.

Cellular and Molecular Gastroenterology and Hepatology
|September 25, 2021
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
07:46

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo

Published on: October 11, 2022

3.6K
Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts
06:57

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts

Published on: February 6, 2021

7.8K

Related Experiment Videos

Last Updated: Oct 19, 2025

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
07:46

Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo

Published on: October 11, 2022

3.6K
Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts
06:57

Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts

Published on: February 6, 2021

7.8K

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.8K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.8K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K

Articles linked to this work by shared authors, journal, and citation graph.

Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition.

Cell stem cell·2026

ETV1 is a key regulator of enteroendocrine PYY production.

Disease models & mechanisms·2025

Deep visual proteomics reveals an in vivo-like phenotype of orthotopically transplanted human colon organoids.

Cell systems·2025

Selective Lysine Ubiquitination Using Activated Phenol Esters.

Chembiochem : a European journal of chemical biology·2025

An integrated transcriptomic cell atlas of human endoderm-derived organoids.

Nature genetics·2025

3D bioprinting of human iPSC-derived cardiac constructs with microvascular network support for improved graft survivalin vivo.

Biofabrication·2025

AOAH-mediated LPS inactivation limits macrophage endotoxin tolerance and promotes inflammation and fibrosis in MASH.

Cellular and molecular gastroenterology and hepatology·2026

Trimethylamine N-oxide, a bariatric surgery-associated host-microbial co-metabolite, reduces colonic tumorigenesis in a sex-dependent manner.

Cellular and molecular gastroenterology and hepatology·2026

Hepatitis B surface antigen directly alters Dendritic cell-mediated Natural Killer cell responses.

Cellular and molecular gastroenterology and hepatology·2026

Thermoneutrality accelerates a distinctive metabolic dysfunction-associated steatohepatitis phenotype in a diet-induced male mouse model with similarities to human disease.

Cellular and molecular gastroenterology and hepatology·2026

Evolutionarily conserved epigenetic regulation of transcriptional cell states during vertebrate pancreatic tumorigenesis.

Cellular and molecular gastroenterology and hepatology·2026

Suppressing FUT8 with a Novel Small Molecule Inhibitor Ameliorates Inflammation in Murine T Cell-mediated Colitis Models.

Cellular and molecular gastroenterology and hepatology·2026

Evaluation of serum antioxidant markers and calcium levels in women with Arthritis.

Pakistan journal of medical sciences·2026

Targeting metabolic reprogramming in cancer: Past, present, and future.

Pharmacology & therapeutics·2026

Curcumin in pancreatic cancer: A comprehensive review of anticancer mechanisms, EMT modulation, and clinical challenges.

Cancer treatment and research communications·2026

Disruption of cellular timekeeping in cancer: links between circadian clocks, metabolism, and tumor progression.

Molecular biology reports·2026

Cancer-Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple-Negative Breast Cancer via Exosomal circFAD104-Mediated Intercellular Communication.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Differential regulation of the proliferative and autophagic responses in murine and human pancreatic cancer cells.

Autophagy reports·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us