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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

477
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
477
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

22
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
22
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

544
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
544

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Related Experiment Video

Updated: Oct 19, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery.

Henrique Carrêlo1, Paula I P Soares1, João Paulo Borges1

  • 1CENIMAT/i3N, Departamento de Ciência dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.

Gels (Basel, Switzerland)
|September 25, 2021
PubMed
Summary

Injectable hydrogel-microparticle composites offer a promising drug delivery system (DDS) for targeted therapies. These systems protect therapeutic agents and enable controlled, sequential release for enhanced synergistic treatment outcomes.

Keywords:
bioactive cargobiomedical applicationsdrug delivery systemshydrogelsmicroparticles

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery

Background:

  • Hydrogels and microparticles are established biocompatible and biodegradable matrices for drug delivery.
  • Composite systems combining hydrogels and microparticles offer enhanced protection and controlled release of bioactive cargo.
  • In situ injectable systems are desirable for localized and efficient therapeutic agent delivery.

Purpose of the Study:

  • To review and analyze studies on in situ injectable microparticle-hydrogel composite drug delivery systems (DDS).
  • To highlight the advantages of these composite DDS for biomedical applications.
  • To discuss the potential for sequential and synergistic drug release in these systems.

Main Methods:

  • Literature review and analysis of existing research on microparticle-hydrogel composites for DDS.
  • Compilation and synthesis of data from various studies focusing on injectable composite systems.
  • Evaluation of the reported properties and performance of these systems in biomedical contexts.

Main Results:

  • Microparticle-hydrogel composites can be formulated as injectable systems for localized drug delivery.
  • The hydrogel matrix protects encapsulated microparticles and modulates the release kinetics of bioactive cargo.
  • These composite DDS facilitate tunable and sequential release profiles, enabling combination therapies.

Conclusions:

  • In situ injectable microparticle-hydrogel composites represent a versatile platform for advanced drug delivery.
  • These systems offer significant advantages in protecting therapeutic agents and achieving controlled, synergistic release.
  • Further development of these composite DDS holds great promise for improving therapeutic efficacy in biomedicine.