MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Area of Science:

• Genetics
• Neurology
• Epidemiology

Background:

• Previous studies on the MTHFR A1298C gene polymorphism and stroke risk have yielded inconclusive and controversial results.
• A comprehensive meta-analysis was needed to clarify the association between this specific gene polymorphism and stroke susceptibility.

Purpose of the Study:

• To accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility through a meta-analysis.

Main Methods:

• A systematic literature search was conducted across multiple databases (Embase, Pubmed, Web of Science, Cochrane Library, CNKI, WanFang).
• Data from 40 articles, comprising 5725 cases and 8655 controls, were analyzed.
• Pooled odds ratios (OR), 95% confidence intervals (CI), and p-values were calculated. Publication bias was assessed using funnel plots and Begger's regression test. Statistical analysis was performed using Stata 12.0.

Main Results:

• A significant relationship was found between MTHFR A1298C polymorphisms and stroke risk across allelic, dominant, and recessive genetic models.
• Subgroup analyses revealed a clear correlation in Asian populations, across different stroke types, and in adult populations.
• Further correlations were observed in studies with hospital-based controls and specific case sizes.

Conclusions:

• The meta-analysis provides evidence supporting a correlation between MTHFR A1298C polymorphism and stroke susceptibility.
• This association is particularly notable in adult populations and for ischemic stroke cases.