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Chikungunya and arthritis: An overview
Rajesh Kumar1, Shubbir Ahmed1, Hilal Ahmad Parray1
1Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Travel Medicine and Infectious Disease
|September 26, 2021
Summary
Chikungunya virus (CHIKV) causes a febrile illness with long-term joint pain. This review covers CHIKV, its arthritis, and current treatment strategies, highlighting knowledge gaps in viral infection mechanisms.
Area of Science:
- Virology
- Immunology
- Rheumatology
Background:
- Chikungunya virus (CHIKV) is an emerging arthropod-vectored virus causing febrile illness with persistent arthralgia and myalgia.
- Outbreaks occur globally, including Africa, Asia, the Americas, and Europe.
- Current treatment is symptomatic; no vaccines or specific antivirals exist.
Purpose of the Study:
- To provide a comprehensive review of chikungunya and CHIKV.
- To outline the history of alphavirus arthritis research.
- To discuss findings on CHIKV-induced arthritis and therapeutic strategies.
Main Methods:
- Literature review of chikungunya and CHIKV research.
- Analysis of pathophysiological similarities between chikungunya arthritis and rheumatoid arthritis.
- Overview of current and potential therapeutic interventions.
Main Results:
- CHIKV infection leads to significant long-term joint pain and muscle aches.
- Alphaviruses share pathophysiological similarities, informing arthritis research.
- Understanding viral mechanisms in arthritis remains incomplete.
Conclusions:
- Further research is needed to elucidate the mechanisms of CHIKV infection and arthritis.
- Development of vaccines, immunotherapies, and antivirals is crucial.
- Exploring novel therapeutic strategies is essential for managing chikungunya sequelae.
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