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Hepatocyte nuclear factor 1A-antisense: Review of its role in the carcinogenesis

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Mohammad Taheri3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|September 26, 2021
PubMed

Insights

Hepatocyte nuclear factor 1A-antisense (HNF1A-AS) long non-coding RNA plays a dual role in cancer development. While often oncogenic, its specific impact on cancer pathoetiology is context-dependent, varying by cancer type.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Hepatocyte nuclear factor 1A-antisense (HNF1A-AS) is a long non-coding RNA (lncRNA) located on chromosome 12q24.31.
  • HNF1A-AS produces at least seven transcripts and is implicated in cancer pathogenesis through HNF1A-dependent and -independent mechanisms.

Purpose of the Study:

  • To review and explain the impact of HNF1A-AS in the pathoetiology of various cancers.
  • To classify existing evidence into preclinical models and human subject investigations.

Main Methods:

  • Systematic review of scientific literature.
  • Classification of evidence from cell line studies, animal models, and clinical investigations.

Main Results:

  • HNF1A-AS is generally considered an oncogenic lncRNA based on substantial evidence.
  • Contradictory findings exist, with HNF1A-AS showing opposite roles in hepatic, gastric, and laryngeal cancers.
  • The role of HNF1A-AS in cancer is context-dependent.

Conclusions:

  • HNF1A-AS exhibits a complex and context-specific role in cancer development.
  • Further research is needed to fully elucidate the dual oncogenic and potentially tumor-suppressive functions of HNF1A-AS across different cancer types.
Keywords:
CancerHNF1A-ASHepatocyte nuclear factor 1A-antisenseLncRNA

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