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Establishing a Dose-Response Relationship Between Opioid Use and Hypogonadism: A Retrospective Case-Control Study.
Yashar Eshraghi1,2, Natalie Hanks2, Scott Rooney1
1Department of Anesthesiology, Interventional Pain Management, Ochsner Clinic Foundation, New Orleans, LA.
Ochsner Journal
|September 27, 2021
Summary
Chronic opioid use is linked to hypogonadism in males. Higher opioid doses increase the risk of developing this condition, impacting quality of life.
Area of Science:
- Endocrinology
- Pharmacology
- Men's Health
Background:
- Opioid-induced androgen deficiency (OPIAD) negatively impacts patient quality of life.
- Chronic opioid use is a common factor in OPIAD.
- Investigating the link between opioid dosage and hypogonadism is crucial.
Purpose of the Study:
- To examine the association between chronic opioid use and hypogonadism.
- To determine if opioid dosage correlates with the incidence of hypogonadism.
Main Methods:
- Retrospective, matched case-control study.
- 357 males (94 cases, 263 controls) aged 18-80 with chronic opioid use.
- Comparison of maximum morphine equivalent daily dose (MEDD) between hypogonadal and non-hypogonadal groups.
Main Results:
- A significant linear association was found between MEDD and hypogonadism risk (P<0.001).
- An odds ratio of 1.44 (95% CI 1.16-1.78) per 100-unit MEDD increase indicated higher odds of hypogonadism.
- Results demonstrate a positive linear relationship between opioid dose and hypogonadism in males.
Conclusions:
- Chronic opioid dose is significantly associated with increased odds of hypogonadism in males.
- Increased clinical suspicion for OPIAD can facilitate earlier symptom recognition.
- This understanding may improve diagnostic accuracy for OPIAD.
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