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Updated: Oct 19, 2025

A Microfluidic-based Hydrodynamic Trap for Single Particles

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

Surface-modified elastomeric nanofluidic devices for single nanoparticle trapping.

Deepika Sharma^1,2,3, Roderick Y H Lim^1,2, Thomas Pfohl^1,4

¹Swiss Nanoscience Institute, 4056 Basel, Switzerland.

Microsystems & Nanoengineering

|September 27, 2021

Summary

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Researchers developed a faster method for creating nanofluidic devices for trapping charged nanoparticles. This new technique significantly reduces surface modification time, enabling broader applications in biosensing and diagnostics.

Area of Science:

Nanotechnology
Surface Chemistry
Electrostatics

Background:

Single nanoparticle confinement is crucial for studying charged molecule properties in aqueous environments.
Conventional geometry-induced electrostatic trapping devices use SiOx substrates and require lengthy surface modifications for trapping different charged particles.

Purpose of the Study:

To develop a simpler and faster method for producing surface-modified nanofluidic devices for high-throughput charged single nanoparticle trapping.
To reduce the surface modification time from days to hours.

Main Methods:

Utilized polydimethylsiloxane (PDMS) for fabricating geometry-induced electrostatic trapping devices.
Applied a two-layer polyelectrolyte coating (poly(ethyleneimine) and poly(styrenesulfonate)) to modify the PDMS surface.

Keywords:

Nanofluidics Nanoscience and technology

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Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

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Last Updated: Oct 19, 2025

A Microfluidic-based Hydrodynamic Trap for Single Particles

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

Optical Trapping of Nanoparticles

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Published on: January 15, 2013

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Conducted comparative studies between native PDMS and surface-modified PDMS devices for nanoparticle trapping.

Main Results:

Successfully reduced nanofluidic device surface modification time from approximately 5 days to a few hours.
Achieved homogeneous surface charge density within the fluidic devices after modification.
Demonstrated equivalent trapping strengths for both surface-modified and native PDMS devices, indicating successful and efficient modification.

Conclusions:

The novel PDMS-based approach offers a significantly faster and simpler route to surface-modified nanofluidic devices.
This advancement facilitates broader applications of geometry-induced electrostatic trapping in biosensing, disease diagnosis, molecular analysis, and pathogen detection.