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Acute Generalized Exanthematous Pustulosis Induced by Cetuximab
Sadia Masood1, Mohammad Rizwan1, Saira Fatima2
1Dermatology, Aga Khan University Hospital, Karachi, PAK.
Cureus
|September 27, 2021
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction that can occur with cetuximab treatment. This case report highlights AGEP as a potential adverse effect of cetuximab in cancer patients.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Cutaneous pustular eruptions can arise from various diseases and medications.
- Acute generalized exanthematous pustulosis (AGEP) is a distinct drug-induced dermatosis characterized by widespread pustules.
- Systemic drugs are common culprits for AGEP.
Observation:
- A 66-year-old male with glottis squamous cell carcinoma developed a fever and widespread pustular eruption post-cetuximab injection.
- Clinical presentation included erythematous papules and pustules on the face, trunk, and limbs.
- Histopathological examination confirmed the diagnosis of AGEP.
Findings:
- This case represents a rare association between AGEP and the biological agent cetuximab.
- Cetuximab-induced AGEP is an extremely rare but documented adverse effect.
- Cessation of cetuximab and supportive treatment led to complete symptom resolution.
Implications:
- Physicians should consider AGEP as a potential side effect of cetuximab therapy.
- Awareness of this adverse effect is crucial for proper diagnosis and patient management.
- Prompt recognition and intervention can lead to favorable patient outcomes.
