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Factors Affecting Prevalence of Urinary Tract Infection in Neonates with Unexplained Hyperbilirubinemia: A Systematic

Fahimeh Bagheri Amiri1, Sanaz Tavasoli1, Nasrin Borumandnia1

  • 1Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Public Health
|September 27, 2021
PubMed

Insights

Urinary tract infection (UTI) affects 6.81% of Iranian neonates with unexplained hyperbilirubinemia. Male gender and low birth weight significantly increase UTI risk in this vulnerable population.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Urinary tract infection (UTI) prevalence and risk factors in neonates with unexplained hyperbilirubinemia require further investigation.
  • UTI prevalence varies geographically, necessitating region-specific data.

Purpose of the Study:

  • To determine the pooled prevalence of UTI in Iranian neonates presenting with unexplained hyperbilirubinemia.
  • To identify risk factors associated with UTI in this specific neonatal population.

Main Methods:

  • A meta-analysis was conducted using data from 2000-2018.
  • International (Web of Science, PubMed, Scopus, Google Scholar) and national (Science Information Database, Magiran) databases were searched.
  • Keywords included "Urinary Tract Infections OR UTI", "urine OR culture OR microbio", "jaundice OR icter OR hyperbili", and "Iran".

Main Results:

  • A total of 4210 neonates from 17 studies were analyzed.
  • The pooled prevalence of UTI was 6.81% (95% CI: 4.86-8.77).
  • Higher UTI prevalence was observed in neonates with prolonged jaundice, low birth weight, and exclusive breastfeeding. Male gender and low birth weight approximately doubled the risk of UTI.

Conclusions:

  • A significant prevalence of UTI exists in neonates with unexplained hyperbilirubinemia.
  • Given the identified risk factors, screening for UTI is crucial in the workup of these neonates.
Abstract

Keywords:
HyperbilirubinemiaIranMeta-analysisNeonatesSystematic reviewUrinary tract infection

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