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Updated: Oct 19, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
Published on: April 23, 2016
Processed pseudogenes: A substrate for evolutionary innovation: Retrotransposition contributes to genome evolution by
Robin-Lee Troskie1, Geoffrey J Faulkner1,2, Seth W Cheetham1
1Mater Research Institute, University of Queensland, Woolloongabba, Australia.
Abstract:
Processed pseudogenes may serve as a genetic reservoir for evolutionary innovation. Here, we argue that through the activity of long interspersed element-1 retrotransposons, processed pseudogenes disperse coding and noncoding sequences rich with regulatory potential throughout the human genome. While these sequences may appear to be non-functional, a lack of contemporary function does not prohibit future development of biological activity. Here, we discuss the dynamic evolution of certain processed pseudogenes into coding and noncoding genes and regulatory elements, and their implication in wide-ranging biological and pathological processes. Also see the video abstract here: https://youtu.be/iUY_mteVoPI.
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