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Bone-Adhesive Hydrogels Based on Dual Crosslinked Poly(2-oxazoline)s.

María J Sánchez-Fernández1, Jens Rutjes1, Rosa P Félix Lanao2

  • 1Department of Dentistry-Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, 6525 EX, the Netherlands.

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|September 27, 2021
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Summary

Researchers developed advanced dual crosslinked hydrogels for bone fracture fixation. These bone-adhesive hydrogels offer superior mechanical and adhesive properties compared to current sealants.

Keywords:
alendronatebone-adhesiveglueshydrogelspoly(2-oxazoline)s

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Orthopedic Surgery

Background:

  • Developing effective bone glues for fracture fixation is challenging.
  • Existing bone adhesives often lack sufficient mechanical strength or bone affinity.
  • Hydrogels offer potential for bone tissue engineering and repair.

Purpose of the Study:

  • To synthesize dual crosslinked hydrogels with tunable stiffness, ductility, and self-healing capacity for bone fracture fixation.
  • To enhance bone adhesion through specific polymer functionalization.
  • To evaluate the mechanical and adhesive properties of the novel hydrogels compared to commercial standards.

Main Methods:

  • Synthesis of dual crosslinked hydrogels using N-hydroxysuccinimide-functionalized poly(2-oxazoline)s (POx-NHS) and amine-functionalized poly(2-oxazoline)s.
  • Incorporation of alendronate-functionalized poly(2-oxazoline)s (POx-Ale) for bone mineral phase affinity.
  • Physical crosslinking with calcium ions to form a double network structure.
  • Assessment of mechanical properties, bone adhesion, and stability in various solutions.

Main Results:

  • Successfully synthesized dual crosslinked hydrogels with tunable stiffness, ductility, and self-healing properties.
  • Achieved superior bone-adhesive properties compared to commercial fibrin sealants, even under wet conditions.
  • Demonstrated excellent in vitro stability in phosphate-buffered saline and ethylenediaminetetraacetic acid solutions.
  • Hydrogels exhibited strong affinity towards the calcium mineral phase of bone.

Conclusions:

  • The developed dual crosslinked hydrogels show significant potential as advanced bone-adhesive glues.
  • These hydrogels offer a promising alternative for facile bone fracture fixation.
  • Further research is warranted to explore their full clinical application potential.