Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.3K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

2.4K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
2.4K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.1K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.1K
Overview of the Vascular System01:20

Overview of the Vascular System

3.1K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.1K
Vascular Resistance01:20

Vascular Resistance

7.8K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of diagnostic KASP markers for MYMIV resistance in urdbean.

Frontiers in genetics·2026
Same author

Dynamical Symbiosis of Solar Cell and Memristor.

ACS energy letters·2026
Same author

Early Management of Unilateral Cleft Lip, Alveolus, and Palate by Presurgical Nasoalveolar Molding: A Case Series of Five Cases.

International journal of clinical pediatric dentistry·2026
Same author

Artificial intelligence and machine learning in robotic, teleoperated, and remote surgery: a bibliometric and knowledge mapping analysis (2015-2025).

Journal of robotic surgery·2026
Same author

Predictive modeling and spatiotemporal analysis of gender-based violence in Rajasthan, India.

Spatial and spatio-temporal epidemiology·2026
Same author

Clinical Validation of Four Point-of-Care High-Risk HPV Assays, Including Two Reduced-Valency Assays, for Cervical Cancer Screening in Low-Resource Settings.

International journal of cancer·2026
Same journal

Dnmt1 associated <i>Gja1</i> promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury.

Epigenetics·2026
Same journal

Differential CpG methylation in the <i>Interferon Gamma</i> (<i>IFNG</i>) promoter correlates with viral load and transcriptional control in people with HIV.

Epigenetics·2026
Same journal

m6A methylation of circKPNA2 promotes colorectal carcinogenesis by activating the RIN1-Ras pathway.

Epigenetics·2026
Same journal

The epigenetic archaeology of human-dog companionship.

Epigenetics·2026
Same journal

LncRNA MIR4435-2HG-mediated succinylation of USF1 promotes its protein stability and induces epithelial-mesenchymal transition in HNSCC.

Epigenetics·2026
Same journal

A relative methylation ordering biomarker of lactylation-related genes predicts prognosis and therapeutic response in cutaneous melanoma.

Epigenetics·2026
See all related articles

Related Experiment Video

Updated: Oct 19, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

10.0K

Sirtuin1 in vascular endothelial function, an overview.

Jitendra Kumar1, Santosh Kumar1

  • 1François M. Abboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA.

Epigenetics
|September 27, 2021
PubMed
Summary
This summary is machine-generated.

Sirtuin1, a key enzyme, regulates lifespan and metabolism. This review details its specific roles in vascular health, focusing on how it controls endothelial function through direct protein interactions.

Keywords:
Sirtuin1deacetylationendothelial functionvascular function

More Related Videos

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.4K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.9K

Related Experiment Videos

Last Updated: Oct 19, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

10.0K
Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.4K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.9K

Area of Science:

  • Molecular Biology
  • Cardiovascular Physiology
  • Aging Research

Background:

  • Sirtuin1 (NAD+-dependent deacetylase) is a crucial regulator of metabolism and organismal lifespan.
  • It plays a significant role in cardiovascular pathophysiology by deacetylating key proteins.
  • Sirtuin1 exhibits tissue-specific functions, particularly in maintaining vascular endothelial homeostasis.

Purpose of the Study:

  • To review the direct targets of Sirtuin1 involved in vascular endothelial function.
  • To elucidate the complex cross-talk between Sirtuin1 and its targets in regulating vascular physiology.
  • To highlight the importance of understanding Sirtuin1's organ and tissue specificity.

Main Methods:

  • Review of existing literature on Sirtuin1's role in vascular biology.
  • Summary of studies identifying direct protein targets of Sirtuin1.
  • Analysis of Sirtuin1's function in endothelial homeostasis and inflammatory pathways.

Main Results:

  • Sirtuin1 directly deacetylates critical proteins influencing cardiovascular health.
  • In the vasculature, Sirtuin1 regulates endothelial homeostasis by controlling inflammatory mediators, oxidants, and transcription factors.
  • Sirtuin1's expression and function are reciprocally regulated by its target proteins.

Conclusions:

  • Sirtuin1 is a vital regulator of vascular endothelial function with significant implications for cardiovascular health.
  • Understanding the tissue-specific actions and regulatory networks of Sirtuin1 is essential for therapeutic targeting.
  • This review provides a comprehensive overview of Sirtuin1's molecular mechanisms in vascular physiology.