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Microbiome First Medicine in Health and Safety.

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Microbiome-First Medicine redefines healthcare by focusing on the human superorganism, starting with the microbiome. This approach combats the epidemic of chronic disorders linked to microbiome damage and promotes lifelong health.

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Area of Science:

  • Microbiome research
  • Systems biology
  • Human physiology

Background:

  • Current medicine often overlooks the microbiome, treating the body as a single species.
  • This has led to unintended microbiome damage, contributing to chronic disorders and increased disease susceptibility.
  • The epidemic of noncommunicable diseases (NCDs) is linked to microbiome disruption.

Purpose of the Study:

  • To present a 21st-century healthcare paradigm: Microbiome-First Medicine.
  • To explore microbiome-human physiology through systems biology.
  • To detail the role of factors damaging the microbiome in the NCD epidemic.

Main Methods:

  • Systems biology approach to microbiome-human physiology.
  • Analysis of the NCD epidemic and contributing factors.
  • Case examples of asthma and obesity comorbidities.

Main Results:

  • Conventional medical practices can inadvertently harm the microbiome.
  • Damage to the microbiome is associated with NCDs, infectious disease susceptibility, and multimorbidity.
  • Asthma and obesity serve as examples of NCDs with extensive comorbid networks.

Conclusions:

  • Prioritizing the microbiome is crucial for sustainable healthcare.
  • Microbiome-First Medicine can mitigate NCDs and improve health across the lifespan.
  • Targeting keystone bacteria and critical developmental windows offers therapeutic potential.