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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse

Rodney R Dietert1, Janice M Dietert2

  • 1Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.

Microorganisms
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Adverse childhood experiences (ACEs) disrupt biological rhythms and aging. This review highlights how managing the gut microbiome can help reverse ACE-programmed chronic diseases and premature aging by restoring biological cycles.

Keywords:
adverse childhood experiences (ACEs)chronic disorderscircadian rhythmsearly life programminggerobioticshealthspanmicrobiomemicroimmunosomenoncommunicable diseases and conditions (NCDs)sleep disorders

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Area of Science:

  • Microbiome research
  • Systems biology
  • Preventative medicine

Background:

  • Adverse childhood experiences (ACEs) are linked to disrupted biological cycles, premature aging, and chronic diseases.
  • The role of the microbiome in ACE-related dysbiosis and dysfunction is increasingly recognized.
  • Current deprogramming efforts for ACEs have not significantly focused on microbiome interventions.

Purpose of the Study:

  • To examine the utility of microorganism-based, anti-aging approaches for combating ACE-programmed chronic diseases (NCDs).
  • To explore how microbiome regulation influences core systems biology cycles and NCD comorbidity risk.
  • To identify opportunities for deprogramming ACE-driven chronic disorders through microbiome management.

Main Methods:

  • Review of scientific literature on microbiota influence on host-microbe interactions.
  • Analysis of microbiota's role in regulating circadian cycles, sleep, and lifespan.
  • Discussion of inflammation and oxidative stress as targets for microbiome intervention.

Main Results:

  • Microbiota significantly influence circadian rhythms, sleep quality, immune function, and inflammation.
  • Gut microbiota regulate the 'microimmunosome' and other systems biology targets.
  • Correcting inflammation and oxidative stress via microbiome management protects telomere length and extends healthspan.

Conclusions:

  • Managing the human holobiont microbiome is crucial for reversing ACE-programmed NCDs and premature aging.
  • Microbiome-based strategies offer a novel approach to deprogram ACE-related health consequences.
  • Integrating microbiome management into routine healthcare and preventative medicine is recommended across the life course.