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Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms

Sylwia Iwańczyk1, Tomasz Lehmann2, Artur Cieślewicz3

  • 1Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznań, Poland.

Biomedicines
|September 28, 2021
PubMed

Insights

Coronary artery abnormal dilation (CAAD) is linked to higher vascular endothelial growth factor (VEGF) levels. Pathological angiogenesis and inflammation are key factors in the development of CAAD.

Area of Science:

  • Cardiovascular Research
  • Angiogenesis Studies
  • Inflammation Research

Background:

  • Coronary artery abnormal dilation (CAAD) pathogenesis is not fully understood.
  • The role of angiogenic and inflammatory factors in CAAD requires further investigation.

Purpose of the Study:

  • To evaluate plasma concentrations of key angiogenic and inflammatory factors in patients with CAAD.
  • To determine the association between these factors and the development of CAAD.

Main Methods:

  • Sandwich ELISA technique was employed to measure plasma levels of MMP-8, TGF-β1, Angiopoietin-2, VEGF, and FGF.
  • Plasma samples were analyzed from three groups: CAAD patients, coronary artery disease (CAD) patients, and normal coronary arteries (NCA) controls.

Main Results:

  • Significantly elevated plasma concentrations of vascular endothelial growth factor (VEGF) were observed in CAAD patients compared to controls (p = 0.002).
  • Elevated VEGF suggests a role for pathological angiogenesis in CAAD.
  • The findings indicate a potential link between inflammation and aneurysmal dilatation of coronary arteries.

Conclusions:

  • Pathological angiogenesis, indicated by elevated VEGF, plays a crucial role in the pathogenesis of CAAD.
  • Inflammatory processes are also implicated as significant contributors to the development of coronary artery aneurysms.

Keywords:
angiogenesiscoronary aneurysmcoronary artery disease

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