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Early Weaning Affects Liver Antioxidant Function in Piglets.

Lihuai Yu1, Hongmin Li1, Zhong Peng1

  • 1School of Animal and Technology, Yangzhou University, Yangzhou 225009, China.

Animals : an Open Access Journal From MDPI
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

Early weaning negatively impacts piglet growth and liver health. Weaning reduces body weight, slows liver development, and impairs antioxidant function, affecting key enzymes and signaling pathways.

Keywords:
antioxidanthepatocytesliverpigletsweaning

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Area of Science:

  • Animal Science
  • Physiology
  • Biochemistry

Background:

  • Early weaning is a common practice in pig production.
  • Weaning stress can affect physiological development and health.
  • Antioxidant function plays a crucial role in mitigating stress-induced damage.

Purpose of the Study:

  • To investigate the effects of early weaning on the antioxidant status in piglet livers.
  • To assess the impact of weaning on liver development and antioxidant enzyme activity.
  • To analyze the modulation of Nrf2 signaling pathway in response to early weaning.

Main Methods:

  • Comparison of suckling piglets (SG) and weaned piglets (WG) at 21 days old.
  • Measurement of body weight, liver index, and hepatocyte morphology.
  • Assay of antioxidant enzyme activities (SOD, CAT, GSH-Px).
  • Analysis of antioxidant enzyme gene expression and Nrf2 signaling pathway.

Main Results:

  • Weaning significantly decreased body weight, liver weight, and liver index (p < 0.01).
  • Hepatocyte size was reduced in weaned piglets (p < 0.05).
  • Antioxidant enzyme activities (SOD, CAT) and GSH-Px gene expression were reduced post-weaning (p < 0.05).
  • Nrf2 and NQO1 gene expression showed altered patterns in weaned piglets.

Conclusions:

  • Early weaning impairs piglet growth and liver development.
  • Weaning compromises liver antioxidant function by reducing enzyme activity and gene expression.
  • The Nrf2 signaling pathway may be affected by early weaning stress.