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Erectile Dysfunction in Men Burdened with the Familial Occurrence of Coronary Artery Disease

Dariusz Kałka1,2, Jana Gebala3, Małgorzata Biernikiewicz4

  • 1Cardiosexology Unit, Department of Physiology & Pathophysiology, Wrocław Medical University, 50-368 Wrocław, Poland.

Journal of Clinical Medicine
|September 28, 2021
PubMed

Insights

Familial coronary artery disease (CAD) was linked to a lower incidence of erectile dysfunction (ED) in men with CAD, despite increased risk factors like hypertension and smoking. Age and education influenced these findings.

Area of Science:

  • Cardiovascular Medicine
  • Urology
  • Genetics

Background:

  • Erectile dysfunction (ED) and coronary artery disease (CAD) share common risk factors, including genetic and lifestyle influences.
  • Familial occurrence of CAD may impact ED prevalence and associated risk factors in men with established CAD.

Purpose of the Study:

  • To investigate the association between familial CAD and the presence of ED in men with CAD.
  • To determine if familial CAD influences the prevalence of classic ED risk factors.

Main Methods:

  • Cross-sectional observational study of 751 men undergoing cardiac rehabilitation for CAD.
  • Data collected on familial CAD history, ED presence, International Index of Erectile Function 5 (IIEF-5) scores, and risk factors (hypertension, dyslipidemia, smoking, sedentary lifestyle).

Main Results:

  • ED was prevalent in 75.63% of men with CAD.
  • Men with familial CAD showed a lower incidence of ED (71.53%) compared to those without (78.29%).
  • Familial CAD was associated with increased hypertension, dyslipidemia, and smoking, but not sedentary lifestyle; however, ED incidence was not higher.

Conclusions:

  • Familial CAD may be associated with a reduced prevalence of ED in men with CAD, contrary to expectations based on shared risk factors.
  • Age and education appear to modulate the relationship between familial CAD and ED.
  • Further research is needed to elucidate the complex interplay between genetics, lifestyle, CAD, and ED.

Keywords:
cardiovascular diseaseerectile dysfunctionfamily health historyphysical activityrisk factors

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