Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inevitable and avoidable deaths in childhood ALL.

U M Saarinen, J Rapola

    Acta Paediatrica Scandinavica
    |March 1, 1986
    PubMed
    Summary

    Analyzing 37 deaths in childhood acute lymphoblastic leukemia (ALL) over 5 years, researchers found infections and ALL relapse were leading causes. Some deaths were avoidable with better diagnosis and care, highlighting the need for pediatrician education and expert treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transaortic Transcatheter Aortic Valve Implantation as a Second Choice over the Transapical Access.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2015
    Same author

    Severe heart failure and rhabdomyolysis associated with propofol infusion in a burn patient.

    Journal of burn care & research : official publication of the American Burn Association·2014
    Same author

    Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1).

    Kidney international·2006
    Same author

    Bone marrow transplantation in young aspartylglucosaminuria mice: improved clearance of lysosomal storage in brain by using wild type as compared to heterozygote donors.

    Bone marrow transplantation·2004
    Same author

    [Current treatment praxis--from the Internet?].

    Duodecim; laaketieteellinen aikakauskirja·2002
    Same author

    Hematopoietic stem cell transplantation in infantile neuronal ceroid lipofuscinosis.

    Neurology·2001

    Area of Science:

    • Pediatric Oncology
    • Hematology
    • Clinical Research

    Background:

    • Childhood acute lymphoblastic leukemia (ALL) remains a significant cause of mortality in pediatric patients.
    • Understanding the specific causes of death is crucial for improving treatment outcomes and survival rates.

    Purpose of the Study:

    • To analyze the causes of death in a cohort of Finnish children diagnosed with ALL.
    • To identify potentially preventable deaths and factors contributing to mortality in childhood ALL.

    Main Methods:

    • Retrospective analysis of 37 deaths among 100 children with ALL.
    • Follow-up period of 5 years.
    • Categorization of deaths by disease status (induction, remission, relapse) and cause (infection, toxicity, relapse).

    Main Results:

    • Seventeen deaths were attributed to infections, and four to chemotherapy toxicity.
    • Relapse of ALL was the primary cause of death in 16 cases.
    • Ten deaths were deemed 'avoidable,' with 5 potentially preventable through improved diagnosis and therapy.

    Conclusions:

    • Infections and ALL relapse are major contributors to mortality in childhood ALL.
    • Enhanced pediatrician education, clinical expertise, and centralized care may reduce avoidable deaths.
    • Continuous improvement in diagnosis and therapy is essential for diminishing mortality in childhood ALL.

    Related Experiment Videos