3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications.

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Biomedical Engineering

Background:

• Three-dimensional (3D) printing is revolutionizing pharmaceutical manufacturing, enabling personalized oral dosage forms.
• Current limitations include a lack of specific guidelines for mechanical properties like hardness and friability for 3D-printed tablets.
• Integrating 3D printing into clinical practice requires addressing quality standards and regulatory frameworks.

Purpose of the Study:

• To review factors influencing the mechanical properties of 3D-printed oral dosage forms.
• To explore the use of excipients and printing parameters for structural integrity.
• To highlight the potential of computational methods and AI in designing 3D-printed tablets.

Main Methods:

• Literature review of factors affecting mechanical properties in 3D-printed oral dosage forms.
• Analysis of excipient selection and printing parameter optimization.
• Exploration of computational modeling and artificial intelligence in tablet design.

Main Results:

• Mechanical properties of 3D-printed dosage forms are influenced by material selection, printing parameters, and post-processing techniques.
• Tailoring excipients and printing processes can ensure structural integrity and desired drug release profiles.
• Computational methods offer a promising approach for designing 3D tablets with predictable mechanical performance.

Conclusions:

• Further research and regulatory development are needed for the widespread clinical adoption of 3D-printed oral dosage forms.
• Optimizing mechanical properties through careful selection of excipients and printing parameters is crucial for quality control.
• The integration of computational tools and AI holds significant potential for advancing the design and manufacturing of personalized 3D-printed medicines.