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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Osteosarcoma in Children: Not Only Chemotherapy.

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Summary

Osteosarcoma (OS) is a severe bone cancer with poor survival rates. This review explores innovative therapeutic strategies to improve outcomes for OS patients, addressing treatment resistance and side effects.

Keywords:
TKIschemoresistanceimmunotherapyiron chelationlncRNAosteosarcomaproteasome inhibitorstherapy

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Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Medical Biochemistry

Background:

  • Osteosarcoma (OS) is a primary bone malignancy known for its heterogeneity, chemoresistance, and metastatic potential.
  • Current 5-year survival rates are approximately 67% for localized disease and 20% for metastatic OS.
  • Standard treatment involves chemotherapy, surgery, and further chemotherapy, often with significant side effects.

Purpose of the Study:

  • To review novel therapeutic strategies for osteosarcoma.
  • To address limitations of current treatments, including chemoresistance and side effects.
  • To explore innovative approaches for improving patient survival and quality of life.

Main Methods:

  • Literature review of recent advancements in osteosarcoma therapeutics.
  • Analysis of emerging treatment modalities and their potential impact.
  • Synthesis of information on innovative strategies targeting OS biology and microenvironment.

Main Results:

  • Identification of several promising innovative therapeutic avenues for osteosarcoma.
  • Discussion of strategies aimed at overcoming chemoresistance and reducing treatment toxicity.
  • Highlighting the potential of novel agents and approaches in preclinical and clinical studies.

Conclusions:

  • Novel therapeutic strategies are crucial for improving osteosarcoma outcomes.
  • Addressing tumor heterogeneity and the bone microenvironment is key.
  • Further research into innovative treatments offers hope for enhanced patient survival and reduced side effects.