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Serotonin levels in hypertension.

M L Biondi, A Agostoni, B Marasini

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |April 1, 1986
    PubMed
    Summary
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    Essential hypertension patients exhibit elevated plasma serotonin and increased serotonin release from platelets. These findings suggest serotonin

    Area of Science:

    • Biochemistry
    • Cardiovascular Research
    • Neuropharmacology

    Background:

    • Essential hypertension is a complex cardiovascular disease.
    • The role of neurotransmitters like serotonin (5-hydroxytryptamine) in hypertension is not fully understood.

    Purpose of the Study:

    • To investigate the involvement of serotonin in the pathogenesis of essential hypertension.
    • To quantify intraplatelet and plasma free serotonin levels in hypertensive patients.

    Main Methods:

    • High-performance liquid chromatography with electrochemical detection was used.
    • Serotonin levels were measured in platelets and plasma of six untreated essential hypertension patients.
    • Serotonin release from platelets stimulated by collagen or adenosine diphosphate (ADP) was assessed.

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    Main Results:

    • Platelet serotonin content was comparable between hypertensive patients and controls.
    • Hypertensive patients displayed significantly higher plasma free serotonin levels.
    • A significantly greater release of serotonin from aggregating platelets was observed in hypertensive patients.

    Conclusions:

    • Serotonin may play a role in the development of essential hypertension.
    • Elevated plasma serotonin and increased platelet release are potential contributors to hypertension pathogenesis.