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Tumor mutational burden and immunotherapy in gliomas

Mythili Merchant1, Alice Ranjan1, Ying Pang1

  • 1Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Trends in Cancer
|September 28, 2021
PubMed
Abstract

Keywords:
gliomasimmunotherapyneoantigenstumor mutational burden

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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