Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

160
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
160
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

39.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
39.7K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

240
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
240
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

3.2K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
3.2K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

452
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
452

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice.

Endocrine connections·2026
Same author

Endocrine regulation of circadian rhythms.

Npj biological timing and sleep·2026
Same author

The timing of antenatal glucocorticoids determines the receptor sensitivity in preterm infants.

The Journal of clinical endocrinology and metabolism·2026
Same author

Effects of Prednisolone Administration on Clock Gene Expression and Indices of Circadian Rhythms in Healthy Human Males.

The Journal of clinical endocrinology and metabolism·2025
Same author

Chiral Metallic DM-EDT-TTF Radical Cation Salts: Anion Size-Dependent Structural and Electronic Transitions, Charge Ordering, and Chirality-Induced Spin Selectivity.

Journal of the American Chemical Society·2025
Same author

Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice.

npj metabolic health and disease..·2025
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
Same journal

The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies.

Seminars in immunopathology·2026
See all related articles

Related Experiment Video

Updated: Oct 18, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K

Glucocorticoid circadian rhythms in immune function.

Iwona Olejniczak1, Henrik Oster2, David W Ray3,4

  • 1Institute of Neurobiology, Center of Brain, Behavior and Metabolism, University of Lübeck, Marie Curie Street, 23563, Lübeck, Germany.

Seminars in Immunopathology
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

Glucocorticoids (GCs) regulate energy, brain, and immune functions with daily rhythms. Understanding these natural GC rhythms is crucial for developing effective chronotherapies for immune diseases.

Keywords:
Adaptive immunityCircadian clockGlucocorticoid rhythmsInnate immunity

More Related Videos

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

179

Related Experiment Videos

Last Updated: Oct 18, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

179

Area of Science:

  • Endocrinology
  • Immunology
  • Chronobiology

Background:

  • Adrenal glucocorticoids (GCs) are vital hormones influencing metabolism, brain function, and immunity.
  • GCs exhibit diurnal rhythms, acting as key signals for circadian clocks in various tissues.
  • Synthetic GC analogues are common immunosuppressants, but their use neglects natural GC rhythms.

Purpose of the Study:

  • To review the circadian regulation of glucocorticoids (GCs).
  • To explore the role of GCs in innate and adaptive immune functions.
  • To discuss the clinical implications of GC circadian dynamics and chronotherapeutics.

Main Methods:

  • Literature review of current knowledge on GC circadian biology.
  • Analysis of studies on GC effects on immune cell function and migration.
  • Examination of research on chronotherapeutic approaches for immune disorders.

Main Results:

  • Endogenous GCs and their daily rhythms prepare the immune system for environmental challenges.
  • Rhythmic GC action influences immune cell migration via chemoattractant expression.
  • Synthetic GCs do not replicate the complex natural rhythms of endogenous hormones.

Conclusions:

  • Circadian dynamics of GCs significantly impact immune system preparedness and function.
  • Chronotherapeutic strategies targeting GC rhythms hold promise for treating immunological diseases like asthma.
  • Further research into natural GC rhythms can optimize clinical applications and patient outcomes.