Antimicrobial mexicanolide limonoids from the seeds of Khaya senegalensis
Yue-Hong Jiang1, Ting-Jun Jiang1, Xiao-Feng Lv1
1Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Abstract:
Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Khaya senegalensis. Their structures were elucidated as senegalenines A-C (1-3) by analysing their 1D/2D NMR and MS spectroscopic analysis. In addition, the isolated limonoids were tested in vitro for antimicrobial potentials against 5 pathogenic microorganisms. Consequently, compounds 1-3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 μg/ml.
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