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Published on: August 16, 2018
Two new triterpenoids from the fruits of Aphanamixis polystachya
Shi-Li Wu1, Qiu-Ping Zou1, Xiao-Yan Xie1
1College of Chinese Materia Medica and Yunnan Key Laboratory of Southen Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China.
Abstract:
Two new triucallane triterpenoids, polystanin F (1) and polystanin G (2), along with eight known compounds (3-10) were isolated from the fruits of Aphanamixis polystachya. Their structures were established on the basis of extensive spectroscopic analysis. Moreover, eight compounds were evaluated for their in vitro cytotoxicity against three cancer cell lines (liver cancer RT112, colon cancer HCT-116 and breast cancer M231) using the MTT method. Compound 7 showed significant cytotoxic activity against HCT-116 with IC50 1.27 μM.
