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Updated: Oct 18, 2025

09:04
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
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Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and "turn-on"
Aleksandr S Oshchepkov1,2, Oksana Reznichenko3, Dan Xu2
1Department of Chemistry and Pharmacy, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany. evgeny.kataev@fau.de.
Abstract:
A novel strategy to design "turn-on" fluorescent receptors for G-quadruplexes of DNA is presented, which relies on the connection of phosphate binding macrocycles (PBM) with naphthalimide dyes. A new PBM-dye family was synthesized and evaluated in terms of binding and detection of nucleotides and DNA G-quadruplexes of different topologies.

