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Updated: Oct 18, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Cu-catalyzed coupling of indanone oxime acetates with thiols to 2,3-difunctionalized indenones
Yuanyuan Fu1, Xueyan Zhao1, Dengfeng Chen1
1Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, People's Republic of China. shuang@njfu.edu.cn.
Abstract:
A Cu-catalyzed coupling reaction of indanone oxime acetates with thiols has been developed for the synthesis of 2,3-functionalized 1-indenones. This protocol has several features including easy mild reaction conditions, stabilized enamine products, good tolerance of functional groups, and no external oxidants. This reaction enables direct derivatization on the indanone ring to provide valuable functionalized indenones at room temperature.
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