Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virus-Mediated Self-Assembly of Functional Cyclodextrins for Antiviral Inhibition.

Angewandte Chemie (International ed. in English)·2026
Same author

Design, Synthesis, and Biological Evaluation of Oligosaccharides Derived from <i>Pleurotus ostreatus</i> Polysaccharide as Potential Neuroprotective Agents.

Journal of medicinal chemistry·2026
Same author

Multivalency Effects: Example of Synthetic Ganglioside GM3 Analogues in the Study of Antitumor Agents.

Journal of medicinal chemistry·2025
Same author

Encapsulating NHC-capped copper(i) complexes inside cyclodextrin for catalysis in living cells.

Chemical science·2025
Same author

Sequential and Time-Controlled Sol-Gel Transitions by Mechanical Switching of Molecular Tweezers.

Journal of the American Chemical Society·2025
Same author

Cyclodextrin-Encapsulated NHCs: Increased Selectivity and Reactivity of CO<sub>2</sub> in Amine Formylation.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024

Related Experiment Video

Updated: Oct 18, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K

Precise Rate Control of Pseudorotaxane Dethreading by pH-Responsive Selectively Functionalized Cyclodextrins.

Sawsen Cherraben1, Jérémy Scelle1, Bernold Hasenknopf1

  • 1Sorbonne Université, CNRS UMR8232, Institut Parisien de Chimie Moléculaire, 4 place Jussieu, 75005 Paris, France.

Organic Letters
|September 28, 2021
PubMed
Summary

Researchers developed amine-functionalized cyclodextrins that control molecular motion on a switchable axle. The pH-dependent substitution pattern on the macrocycle dictates the rate of threading and dethreading, enabling tunable molecular machinery.

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.0K

Related Experiment Videos

Last Updated: Oct 18, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.0K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Molecular machines offer precise control over nanoscale movements.
  • Cyclodextrins are versatile macrocyclic hosts with tunable properties.

Purpose of the Study:

  • To investigate amine-functionalized cyclodextrins for controlling molecular motion.
  • To explore pH-dependent rate control of threading and dethreading on a molecular axle.

Main Methods:

  • Synthesis of cyclodextrins with varying amine functionalization (0, 1, 2, 6 amines).
  • Assembly of cyclodextrin-molecular axle systems.
  • pH-dependent kinetic studies of threading and dethreading rates.

Main Results:

  • The rate of cyclodextrin threading and dethreading was successfully controlled by pH.
  • The degree of amine substitution on the cyclodextrin influenced the switching speed.
  • The system demonstrated stimulus-responsive behavior directly on the macrocycle.

Conclusions:

  • Amine-functionalized cyclodextrins provide a novel strategy for controlling molecular machine dynamics.
  • pH serves as an effective external stimulus to modulate the kinetics of supramolecular systems.
  • This work advances the design of switchable molecular devices.