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Recent progress in nanotechnology-based drug carriers for celastrol delivery
Ling Guo1,2, Yongping Zhang1,2, Khuloud T Al-Jamal2
1Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Dongqing South Road, Huaxi University City, Guiyang, Guizhou 550025, P.R. China.
Biomaterials Science
|September 28, 2021
Summary
Celastrol (CLT), a compound from Tripterygium wilfordii, shows promise for various diseases but faces bioavailability challenges. Nanotechnology offers solutions to enhance its therapeutic potential and delivery.
Area of Science:
- Pharmacology and Nanotechnology
Background:
- Celastrol (CLT) is a potent compound extracted from Tripterygium wilfordii.
- CLT exhibits significant therapeutic potential in treating cancer, obesity, and inflammatory, autoimmune, and neurodegenerative diseases.
- Clinical applications of CLT are severely limited by its poor solubility, low permeability, and potential toxicity.
Purpose of the Study:
- To review recent advancements in nanocarrier systems for Celastrol (CLT).
- To explore how nanotechnology can overcome the limitations of CLT for improved therapeutic outcomes.
Main Methods:
- Comprehensive literature review of nanotechnology-based approaches for Celastrol delivery.
- Analysis of various nanocarrier systems designed to enhance CLT's properties.
Main Results:
- Nanotechnology offers effective strategies to improve Celastrol's oral bioavailability and therapeutic efficacy.
- Various nanocarrier systems demonstrate potential for targeted delivery and reduced off-target toxicity of Celastrol.
- Recent innovations in nanomedicine are paving the way for broader clinical applications of Celastrol.
Conclusions:
- Nanotechnology is a promising solution to enhance the clinical utility of Celastrol (CLT).
- Further research into nanocarrier systems can unlock the full therapeutic potential of Celastrol for diverse diseases.
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