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Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis
Graeme J Koelwyn1, Joseph Pierre Aboumsallem2, Kathryn J Moore3
1Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Abstract:
The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior to or following a cancer diagnosis, can also lead to increased risk of cancer and worse outcomes for patients. In this review, we describe the current evidence base, across epidemiological as well as preclinical studies, which supports the emerging concept of 'reverse-cardio oncology', or CVD-induced acceleration of cancer pathogenesis.
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