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Elderly Hospitalized for COVID-19 and Fever: A Retrospective Cohort Study

Noel Roig-Marín1, Pablo Roig-Rico1,2

  • 1Universidad Miguel Hernández, Campus De San Juan De Alicante, Spain.

Experimental Aging Research
|September 29, 2021
PubMed

Insights

Fever in elderly COVID-19 patients did not impact in-hospital mortality. However, patients without fever showed higher D-dimer and LDH levels, suggesting potentially greater disease severity.

Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 has caused significant mortality globally.
  • Fever is a common symptom, but its prognostic value in elderly COVID-19 patients is not well-defined.
  • Previous research suggests early fever may have a protective effect.

Purpose of the Study:

  • To investigate the relationship between fever and in-hospital mortality in elderly patients admitted with COVID-19.
  • To identify differences in clinical and laboratory parameters between febrile and afebrile elderly COVID-19 patients.

Main Methods:

  • Retrospective analysis of hospital admission records from 2020.
  • Inclusion of elderly patients admitted for COVID-19 at Hospital de San Juan de Alicante, Spain.
  • Comparison of mortality and laboratory values between patients with and without fever.

Main Results:

  • No significant difference in in-hospital mortality was observed between elderly COVID-19 patients with and without fever.
  • Patients without fever were older and had higher comorbidity.
  • Afebrile patients exhibited significantly higher D-dimer and LDH levels, and lower oxygenation parameters (PaO2/FiO2, SpO2/FiO2).

Conclusions:

  • Fever status is not a significant predictor of mortality in elderly COVID-19 patients.
  • Absence of fever in elderly COVID-19 patients may indicate a more severe disease course, evidenced by distinct laboratory findings.
  • Further research is needed to understand the implications of these laboratory differences.
Abstract

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