Related Experiment Video
Updated: Oct 18, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
Published on: November 29, 2024
Orchestrating human neocortex development across the scales; from micro to macro
Marco Massimo1, Katherine R Long1
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
Abstract:
How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.

