Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

1.5K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neocortex Folding in Primates up to Human: Evolution and Mechanisms.

Developmental neuroscience·2025
Same author

ECM Mechanics in Central Nervous System Morphogenesis.

Developmental neuroscience·2025
Same author

The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation.

Disease models & mechanisms·2025
Same author

Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics.

Nature communications·2025
Same author

The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex.

The EMBO journal·2024
Same author

In preprints: shaping the developing human brain.

Development (Cambridge, England)·2023

Related Experiment Video

Updated: Oct 18, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.4K

Orchestrating human neocortex development across the scales; from micro to macro.

Marco Massimo1, Katherine R Long1

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.

Seminars in Cell & Developmental Biology
|September 29, 2021
PubMed
Summary

Scientists are exploring human brain development, focusing on the neocortex. This review summarizes key findings from cellular to whole-brain imaging, integrating diverse research scales to understand complex cognitive functions.

Keywords:
DevelopmentHuman neocortexShapeSize

More Related Videos

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

21.7K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

5.2K

Related Experiment Videos

Last Updated: Oct 18, 2025

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.4K
Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

21.7K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

5.2K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cognitive Science

Background:

  • Understanding human brain evolution and function is a key scientific pursuit.
  • The human neocortex's development is crucial for complex cognitive abilities.
  • Research spans multiple scales, from cellular mechanisms to whole-brain imaging.

Purpose of the Study:

  • To synthesize current knowledge on human neocortex development.
  • To integrate findings from micro- and macroscopic research approaches.
  • To provide a comprehensive overview of brain development mechanisms.

Main Methods:

  • Review of existing scientific literature.
  • Integration of data from cellular and molecular studies.
  • Analysis of neuroimaging studies across different scales.

Main Results:

  • Identification of key regulatory mechanisms in neocortical development.
  • Synthesis of findings from diverse research methodologies.
  • Highlighting the interplay between different developmental scales.

Conclusions:

  • Neocortical development is a complex, multi-scale process.
  • Integrating micro- and macroscopic findings offers a holistic view.
  • Further research integrating these scales is vital for understanding human cognition.