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Updated: Oct 18, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Concurrent Use of E-cigarettes, Combustible Cigarettes, and Marijuana
Thomas A Wills1, Adam Matthew Leventhal2, James D Sargent3
1University of Hawaii Cancer Center, Honolulu, Hawaii twills@cc.hawaii.edu.
Adolescent triple use of e-cigarettes, cigarettes, and marijuana is common and linked to higher psychosocial risks. Understanding these substance use patterns is crucial for prevention efforts.
Area of Science:
- Adolescent health
- Substance use research
- Public health epidemiology
Background:
- Adolescent substance use patterns are evolving, with increased marijuana use alongside e-cigarette and cigarette use.
- Previous research identified subgroups of adolescent e-cigarette and cigarette users, but current patterns including marijuana require updated investigation.
Purpose of the Study:
- To identify and characterize subgroups of adolescent users of e-cigarettes, combustible cigarettes, and marijuana using recent data.
- To determine the behavioral correlates and psychosocial risk profiles associated with these distinct substance use subgroups.
Main Methods:
- Cross-classification of ever and recent use of e-cigarettes, combustible cigarettes, and marijuana among US high school students from the 2019 Youth Risk Behavior Survey (YRBS).
- Comparison of 14 risk and protective factors across eight identified user groups using general linear models.
- Replication of analyses using 2017 YRBS data to ensure consistency of findings.
Main Results:
- Non-users comprised 43.9% of the sample. The most prevalent user groups were triple users (16.9%), dual e-cigarette and marijuana users (15.8%), and exclusive e-cigarette users (13.2%).
- Triple users exhibited significantly elevated psychosocial risk profiles compared to all other groups.
- Exclusive e-cigarette users showed higher risk than non-users but lower risk than dual users of cigarettes and marijuana.
Conclusions:
- The co-occurrence of e-cigarette, cigarette, and marijuana use is substantial among adolescents.
- This polysubstance use is associated with an elevated psychosocial risk profile, highlighting implications for epidemiology and prevention.
- Further research is necessary to understand the prevalence and pathways leading to triple substance use in adolescents.
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