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Atherosclerosis, Ischemia, and Anticancer Drugs
Shailesh Singh1, Katyayni Singh2
1Department of Cardiology, Fortis Escorts Heart Institute, New Delhi, India.
Heart Views : the Official Journal of the Gulf Heart Association
|September 29, 2021
Summary
Anticancer drugs can harm the heart, leading to cardiotoxicity. This review explores how these treatments cause atherosclerosis and ischemic heart complications.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Anticancer drugs can cause cardiotoxicity, affecting heart tissues like the myocardium, pericardium, and endocardium.
- Accelerated atherosclerosis in coronary arteries is a known complication of certain cancer therapies.
- Pathogenic mechanisms linking anticancer drugs to ischemic heart events require further elucidation.
Purpose of the Study:
- To review the atherosclerotic complications of anticancer drugs.
- To discuss the ischemic complications associated with cardiotoxicity induced by anticancer agents.
- To synthesize current understanding of the pathogenic mechanisms involved.
Main Methods:
- Literature review of studies on anticancer drug cardiotoxicity.
- Analysis of reported cases of atherosclerosis and ischemic events in cancer patients treated with chemotherapy.
- Synthesis of proposed pathogenic pathways.
Main Results:
- Anticancer drugs can induce direct myocardial damage and pericardial/endocardial inflammation.
- Accelerated atherosclerosis is a significant risk associated with specific chemotherapeutic agents.
- Multiple mechanisms contribute to drug-induced ischemic heart complications.
Conclusions:
- Cardiotoxicity from anticancer drugs poses a serious threat to cardiovascular health.
- Understanding the mechanisms of atherosclerosis and ischemia is crucial for managing these risks.
- Further research is needed to develop strategies for preventing and treating these adverse effects.
Keywords:
Accelerated atherosclerosisanticancer drugscardio-oncologycoronary artery diseasemyocardial infarctionMore Related Videos
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