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Correlates of gallbladder stones among patients with sickle cell disease: A meta-analysis

Sagad O O Mohamed1, Omer A O Ibrahim2, Dahlia A A Mohammad3

  • 1Department of Paediatrics and Child Health, Faculty of Medicine University of Khartoum Khartoum Sudan.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|September 29, 2021
PubMed

Insights

Gallstones (cholelithiasis) affect about 25% of sickle cell disease (SCD) patients. Lower hemoglobin and higher bilirubin levels are linked to increased gallstone risk in SCD.

Area of Science:

  • Hematology
  • Genetics
  • Gastroenterology

Background:

  • Sickle cell disorders are prevalent global hemoglobinopathies.
  • Sickle cell disease (SCD) exhibits significant clinical variability and complication susceptibility.
  • Cholelithiasis is a common complication in SCD patients.

Purpose of the Study:

  • To summarize and analyze the prevalence of cholelithiasis in SCD patients.
  • To identify factors associated with cholelithiasis development in SCD.

Main Methods:

  • Systematic database search across multiple scientific literature repositories.
  • Meta-analysis of 34 eligible studies using Comprehensive Meta-Analysis Software.
  • Calculation of pooled prevalence, odds ratio (OR), and standardized mean difference (SMD) with 95% confidence intervals (CI).

Main Results:

  • Overall prevalence of cholelithiasis in SCD patients was 25.3% (95% CI 19.4-32.3%).
  • Significant associations found between cholelithiasis and lower total hemoglobin (SMD = -0.45, P = 0.002) and hemoglobin F (HbF) levels (SMD = -0.85, P = 0.003).
  • Higher total serum bilirubin (SMD = 1.15, P < 0.001), higher reticulocyte count (SMD = 0.44, P = 0.007), and UGT1A1 promoter polymorphism were also significantly associated with increased risk.

Conclusions:

  • SCD patients experience a high rate of cholelithiasis.
  • Hematologic parameters like hemoglobin levels and bilirubin are key factors influencing cholelithiasis risk.
  • Genetic factors, specifically UGT1A1 polymorphism, play a role in SCD-related cholelithiasis.

Keywords:
cholelithiasismeta‐analysisprevalence studiessickle cell disease

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