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Updated: Oct 18, 2025
In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
Published on: October 8, 2019
Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced
Kahlan Merriman1, Emily Petruccelli1
1Southern Illinois University Edwardsville.
Abstract:
The Drosophila transcriptional reporter of intracellular calcium (TRIC) is a genetic tool used to measure lasting changes in neuroexcitability. Both pan-neuronal and dopaminergic cells were examined with TRIC to test the hypothesis that ethanol exposure causes lasting changes in adult brain neuroexcitability. We found little to no impact on TRIC signal following acute and repeated ethanol vapor exposures. This work shows that TRIC may be useful in future investigations such as developmental or chronic drug exposure paradigms.
