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Updated: Oct 18, 2025
Morphometric Analyses of Retinal Sections
Published on: February 19, 2012
Chemical constituents from Solanum nigrum and their neuroprotective activities
Ming Bai1, Qian Zhang1, Zi-Lin Hou1
1Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Abstract:
Ten compounds (1-10) including four new compounds (1-4) and six known compounds (5-10) were isolated from Solanum nigrum. Their structures were elucidated on the basis of spectroscopic data, gauge-including atomic orbital (GIAO) calculation of NMR data, DP4+ probability analysis and comparison of their experimental and calculated electronic circular dichroism (ECD) spectral data. All the isolated compounds were tested for their neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 5 and 7 displayed moderate neuroprotective effects.
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