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Amino Appended Coumarin Composites for Pb2+ Capturing in Aqueous Medium
Nidhi Sharma1,2, Ashu Gulati3
1Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Road Research Institute, CRRI, Delhi-Mathura Road, New Delhi, Delhi, 110025, India. sharma_12dec@rediffmail.com.
Abstract:
The C1-C3 receptors were synthesized by using coumarin and amines viz., 1-butylpiperazine (1), cis-myrtanylamine (2), and 3-methyldiphenyl amine (3) at room temperature without using harsh conditions. All the probes show beautiful and strong binding with Pb2+ ions among all the tested essential elements of human body. The binding is clearly seen and confirmed in UV-visible, NMR and HPLC studies. Also, all the substituted amines (1-3) are well known bioactives viz., piperazine as anthelmintic, cis-myrtanyl use for cannabinoid receptor (CB2) antagonists, 3-methyldiphenyl is used in probes for selective detection of explosive nitroaromatic compounds further increases their sensitivity for use as Pb2+ sensor. As they are already well in use for research on human body metabolomics their future introduction as sensors in the human body for lead toxicity is highly favourable.
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