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Real-world Evidence for Adherence and Persistence with Atorvastatin Therapy
Konstantinos Tsioufis1, José María Castellano Vázquez2,3, Georgia Sykara4
1First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece. ktsioufis@hippocratio.gr.
Cardiology and Therapy
|September 29, 2021
Summary
Patient adherence to atorvastatin is suboptimal, impacting low-density lipoprotein cholesterol (LDL-C) goal attainment. Real-world data show limited evidence of differences between branded and generic atorvastatin, but switching may negatively affect long-term adherence.
Area of Science:
- Cardiovascular Medicine
- Pharmacoeconomics
- Real-World Evidence
Background:
- Atorvastatin is a widely prescribed statin for dyslipidemia, yet many patients do not achieve recommended low-density lipoprotein cholesterol (LDL-C) targets.
- Suboptimal patient adherence is a significant barrier to effective dyslipidemia management and achieving therapeutic goals.
Purpose of the Study:
- To review real-world patient adherence and persistence with atorvastatin.
- To identify barriers to LDL-C goal attainment and therapy outcomes.
- To investigate the impact of generic atorvastatin availability on adherence, lipid levels, and efficacy compared to branded formulations.
Main Methods:
- Narrative review of existing literature.
- Targeted literature searches on generic atorvastatin impact.
- Analysis of real-world data on adherence and persistence.
Main Results:
- Real-world adherence and persistence to atorvastatin are suboptimal.
- Limited data exist comparing adherence between branded and generic atorvastatin, with no clear impact from initial prescription.
- Switching from branded to generic atorvastatin may negatively affect long-term adherence, though results are conflicting.
Conclusions:
- Additional real-world studies are needed to understand adherence differences between branded and generic atorvastatin.
- Factors influencing adherence require further investigation.
- Targeted education and research are essential to improve patient adherence and outcomes in real-world settings.
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