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Updated: Oct 18, 2025
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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
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Optical Coherence Tomography Angiography in Patients with Cone Dystrophy
Alper Can Yilmaz1, Ali Hakan Durukan2, Hayati Yilmaz3
1Department of Ophthalmology, Merzifon State Hospital, Amasya, Turkey.
Seminars in Ophthalmology
|September 29, 2021
Summary
Optical coherence tomography angiography (OCTA) reveals reduced macular perfusion in cone dystrophy patients. Visual acuity and electroretinography correlate with OCTA findings, offering insights into disease impact.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Cone dystrophy is a group of inherited retinal diseases affecting cone photoreceptors.
- Assessing macular perfusion is crucial for understanding disease progression and visual function.
- Optical coherence tomography angiography (OCTA) offers a non-invasive method to visualize retinal vasculature.
Purpose of the Study:
- To evaluate macular perfusion using OCTA in patients diagnosed with cone dystrophy.
- To investigate the relationship between quantitative OCTA measurements and functional visual parameters.
Main Methods:
- Analysis of OCTA data from 36 eyes of 18 cone dystrophy patients and 38 eyes of 19 healthy controls.
- Quantification of superficial and deep capillary plexus (SCP and DCP) vessel densities (VD), foveal avascular zone (FAZ), and choriocapillary flow density.
- Correlation analysis between OCTA metrics, visual acuity (VA), and full-field electroretinography (ffERG) parameters.
Main Results:
- Significantly lower SCP vessel density was observed in multiple macular areas in the cone dystrophy group compared to controls.
- Visual acuity demonstrated significant associations with SCP and DCP vessel densities (excluding foveal SCP).
- Visual acuity was also correlated with dark-adapted and light-adapted wave amplitudes from ffERG.
Conclusions:
- OCTA quantitatively confirms reduced macular perfusion in cone dystrophy patients compared to healthy individuals.
- A significant association exists between visual acuity, ffERG parameters, and quantitative OCTA data in cone dystrophy.
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