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Nutritional supplement drink reduces inflammation and postoperative depression in patients after off-pump coronary
Satoshi Matsushita1, Akie Shimada2, Taira Yamamoto2
1Department of Cardiovascular Surgery, Juntendo University Faculty of Medicine, Tokyo 113-8421, Japan. saty-m@juntendo.ac.jp.
Insights
Daily intake of an herbal drink improved cardiac rehabilitation after coronary artery bypass grafting surgery. Patients showed increased daily steps, reduced inflammation, and lower depression scores, aiding recovery.
Area of Science:
- Cardiology
- Integrative Medicine
- Surgical Rehabilitation
Background:
- Coronary artery bypass grafting (CABG) is a key treatment for ischemic heart disease.
- Postoperative rehabilitation can be delayed for some patients despite surgical advancements.
- Investigating novel supportive therapies for enhanced recovery is crucial.
Purpose of the Study:
- To evaluate the efficacy of a daily herbal medicine-containing drink in enhancing postoperative rehabilitation.
- To assess the impact of the supplement on physical activity, inflammatory markers, and psychological well-being.
Main Methods:
- Patients undergoing isolated off-pump coronary artery bypass (OPCAB) surgery were assigned to two groups.
- The intervention group (YKR) received a daily herbal supplement drink.
- The control group (CTL) received standard rehabilitation protocols.
Main Results:
- The YKR group exhibited a significant increase in daily steps post-surgery (P < 0.05).
- Lower postoperative serum tumor necrosis factor-alpha levels were observed in the YKR group (P < 0.01).
- Significant improvement in the Hospital Anxiety and Depression Score was noted in the YKR group (P < 0.05).
Conclusions:
- Daily intake of the herbal drink may positively influence cardiac rehabilitation after OPCAB surgery.
- The supplement appears to reduce inflammation and depression symptoms post-surgery.
- Further research can explore the long-term benefits and specific mechanisms of action.
Background:
Coronary artery bypass grafting is a surgical treatment for ischemic heart disease. Although development in surgical technique and improvement of perioperative management reduced the postoperative complications, some patients still delayed in progress of postoperative rehabilitation. In this study, we aimed to investigate the effect of daily intake of an herbal medicine-containing drink for rehabilitation after surgery in patients with ischemic heart disease.
Aim:
To investigate the effect of taking an herbal medicine-containing, commercially available drink for postoperative rehabilitation in those patients.
Methods:
Patients who underwent isolated off-pump coronary artery bypass (OPCAB) surgery were divided into two groups depend on the timing of the admission to the hospital: the Yunker (YKR) group, that consumed one bottle of a caffeine-free nutritional supplement drink on a daily basis and the control group (CTL) that underwent regular rehabilitation.
Results:
A total of 229 patients (CTL = 130, YKR = 99) were enrolled. No significant differences were observed in the baseline characteristics between the two groups. The YKR group had a significantly increased number of daily steps postoperatively (P < 0.05) and had significantly lower postoperative serum tumor necrosis factor-alpha levels (P < 0.01), while no significant differences were observed in the levels of other inflammatory or stress-related cytokines (interleukin-6, adiponectin, superoxide dismutase, and urine 8-hydroxy-2'-deoxyguanosine) between the two groups. Also, the YKR group showed a significant improvement in the Hospital Anxiety and Depression Score (P < 0.05). Moreover, there were no differences in postoperative complications and the duration of postoperative hospital stay between the two groups.
Conclusion:
Our results demonstrated that the daily intake of an herbal medicine-containing drink after OPCAB surgery may have beneficial effects on cardiac rehabilitation by reducing inflammation markers and depression.
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