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The biology, function, and applications of exosomes in cancer

Jinyi Liu1,2, Liwen Ren1,2, Sha Li1,2

  • 1The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China.

Acta Pharmaceutica Sinica. B
|September 30, 2021
PubMed

Keywords:
ABCA3, ATP-binding cassette transporter A3APCs, antigen-presenting cellsBiomarkersCAFs, cancer-associated fibroblastsCCRCC, clear-cell renal cell carcinomaCD-UPRT, cytosine deaminase-uracil phosphoribosyltransferaseCDH3, cadherin 3CRC, colorectal cancerDC, dendritic cellsDEXs, DC-derived exosomesDLBCL, diffuse large B-cell lymphomaDNM3, dynamin 3Del-1, developmental endothelial locus-1Drug deliveryDrug resistanceECM, extracellular matrixEMT, epithelial–mesenchymal transitionESCRT, endosomal sorting complex required for transportExosomesGPC1, glypican-1HA, hyaluronic acidHCC, hepatocellular carcinomaHIF1, hypoxia-inducible factor 1HTR, hormone therapy-resistantHUVECs, human umbilical vein endothelial cellsILVs, intraluminal vesiclesMDSCs, myeloid-derived suppressor cellsMIF, migration inhibitory factorMSC, mesenchymal stem cellsMVB, multivesicular bodyNKEXOs, natural killer cell-derived exosomesNNs, nanoparticlesNSCLC, non-small cell lung cancerPA, phosphatidic acidPCC, pheochromocytomaPD-L1, programmed cell death receptor ligand 1PDAC, pancreatic ductal adenocarcinomaPGL, paragangliomaPI, phosphatidylinositolPS, phosphatidylserinePTRF, polymerase I and transcript release factorRCC, renal cell carcinomaSM, sphingomyelinSNARE, soluble NSF-attachment protein receptorTEX, tumor-derived exosomesTSG101, tumor susceptibility gene 101Tumor immunityTumor metastasiscircRNAs, circular RNAsdsDNA, double stranded DNAhTERT, human telomerase reverse transcriptaselamp2b, lysosome-associated membrane glycoprotein 2blncRNAs, long non-coding RNAsmiRNA, microRNAmtDNA, mitochondrial DNAncRNA, non-coding RNAs

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